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Proteins/UNIPROT:Q8NCH0
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development..
Function from UniProtKB (Q8NCH0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
32 statements
32 statements · 4 reference databases · Subject: CHST14 · Sources: Hetionet, Human Protein Atlas, Reactome, WikiPathways
5 reactions
MAM01568g+23'-phospho-5'-adenylyl sulfateMAM01518g+2proton+2adenosine 3',5'-bismonophosphate
Catalysed by CHST12 or CHST14 or CHST11 or CHST13
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.5, 2.8.2.35Golgi apparatus
Human-GEM MAR07491CC BY 4.0Reference data
MAM01516g+3'-phospho-5'-adenylyl sulfateMAM01517g+
4 names
Resolves to: CHST14
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07498CC BY 4.0Reference data
MAM01530g+3'-phospho-5'-adenylyl sulfateMAM01531g+proton+adenosine 3',5'-bismonophosphate
Catalysed by CHST12 or CHST14 or CHST11 or CHST13
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.5, 2.8.2.35Golgi apparatus
Human-GEM MAR07509CC BY 4.0Reference data
MAM01565g+3'-phospho-5'-adenylyl sulfateMAM01566g+proton+adenosine 3',5'-bismonophosphate
Catalysed by CHST12 or CHST14 or CHST11 or CHST13
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07551CC BY 4.0Reference data
CHEBI:60059+n3'-phosphoadenylyl sulfateCHEBI:58465+nadenosine 3',5'-bisphosphate+nhydron
Catalysed by CHST14
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:48052CC BY 4.0Reference data