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Proteins/UNIPROT:Q9NRB3
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Function from UniProtKB (Q9NRB3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
18 statements
18 statements · 3 reference databases · Subject: CHST12 · Sources: Hetionet, Reactome, WikiPathways
5 reactions
MAM01568g+23'-phospho-5'-adenylyl sulfateMAM01518g+2proton+2adenosine 3',5'-bismonophosphate
Catalysed by CHST12 or CHST14 or CHST11 or CHST13
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.5, 2.8.2.35Golgi apparatus
Human-GEM MAR07491CC BY 4.0Reference data
MAM01516g+3'-phospho-5'-adenylyl sulfateMAM01517g+
5 names
Resolves to: CHST12
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07498CC BY 4.0Reference data
MAM01530g+3'-phospho-5'-adenylyl sulfateMAM01531g+proton+adenosine 3',5'-bismonophosphate
Catalysed by CHST12 or CHST14 or CHST11 or CHST13
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.5, 2.8.2.35Golgi apparatus
Human-GEM MAR07509CC BY 4.0Reference data
MAM01565g+3'-phospho-5'-adenylyl sulfateMAM01566g+proton+adenosine 3',5'-bismonophosphate
Catalysed by CHST12 or CHST14 or CHST11 or CHST13
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07551CC BY 4.0Reference data
CHEBI:57652+n3'-phosphoadenylyl sulfateCHEBI:58422+nadenosine 3',5'-bisphosphate+nhydron
Catalysed by CHST13 or CHST11 or CHST12
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:16101CC BY 4.0Reference data