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Proteins/UNIPROT:P51685
G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage (By similarity)..
(Microbial infection) Acts as a coreceptor for HIV-1 and HIV-2 viruses..
(Microbial infection) Acts as a receptor for Kaposi virus protein vCCL1/K6 and thereby inhibits apoptosis in the targeted cells..
Function from UniProtKB (P51685), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 4 reference databases · Subject: CCR8 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
13 names
Resolves to: CCR8