Proteins/UNIPROT:O15467

CCL16

ProteinUNIPROT:O15467

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

Function from UniProtKB (O15467), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

24 statements

24 statements · 4 reference databases · Subject: CCL16 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CCL16 covaries with GPATCH2LProteinHetionet hetionet:covaries:55668-6360Inferred only
HEMGN covaries with CCL16ProteinHetionet hetionet:covaries:55363-6360Inferred only
MACF1 covaries with CCL16ProteinHetionet hetionet:covaries:23499-6360Inferred only
RAD54B covaries with CCL16ProteinHetionet hetionet:covaries:25788-6360Inferred only
CCL16 covaries with ZBTB8AProteinHetionet hetionet:covaries:6360-653121Inferred only
ZNF576 covaries with CCL16ProteinHetionet hetionet:covaries:6360-79177Inferred only
CCL16 covaries with ZNF646ProteinHetionet hetionet:covaries:6360-9726Inferred only
CCR1 interacts with CCL16ProteinHetionet hetionet:interacts:1230-6360Inferred only
CCL16 interacts with CCR2ProteinHetionet hetionet:interacts:6360-729230Inferred only
CCR5 interacts with CCL16ProteinHetionet hetionet:interacts:1234-6360Inferred only
CCR8 interacts with CCL16ProteinHetionet hetionet:interacts:1237-6360Inferred only
CXCR5 interacts with CCL16ProteinHetionet hetionet:interacts:6360-643Inferred only

Show the remaining 12

CCL16 interacts with HRH4ProteinHetionet hetionet:interacts:59340-6360Inferred only
CCL16 participates in 17q12 copy number variation syndromePathwayWikiPathways WP5287Inferred only
CCL16 participates in Chemokine receptors bind chemokinesPathwayReactome R-HSA-380108Inferred only
CCL16 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
CCL16 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
CCL16 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
CCL16 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
CCL16 participates in Overview of proinflammatory and profibrotic mediatorsPathwayWikiPathways WP5095Inferred only
CCL16 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
CCL16 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CCL16 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CCL16 regulates positive regulation of cell migrationBiological processgene ontology O15467|GO:0030335Inferred only

Other names

15 names

Resolves to: CCL16

Also called: Chemokine CC-4Chemokine LECHCC-4IL-10-inducible chemokineILINCKLCC-1Liver-expressed chemokineLMCLymphocyte and monocyte chemoattractantMonotactin-1MTN-1NCC-4NCC4SCYA16Small-inducible cytokine A16

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