HRH4

G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses. Mediates chemotaxis of immune cells to sites of inflammation or injury by responding to histamine. Activation by histamine also influences the release of proinflammatory cytokines such as TNF, CCL4, IL6 and IFN-gamma. Ligand binding induces a conformation change that triggers signaling via G(i)/GNAI1 leading to decreased intracellular cAMP levels by inhibiting adenylate cyclase activity. In addition, plays a role in the control of renal reabsorption processes, particularly albumin uptake (By similarity)..

Function from UniProtKB (Q9H3N8), read 2026-09-23. CC BY 4.0.