Proteins/UNIPROT:Q8NEC5

CATSPER1

ProteinUNIPROT:Q8NEC5

Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte..

Function from UniProtKB (Q8NEC5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 4 reference databases · Subject: CATSPER1 · Sources: gene ontology, Hetionet, Reactome, Rhea

Order

CABP7 covaries with CATSPER1ProteinHetionet hetionet:covaries:117144-164633Inferred only
CHL1 covaries with CATSPER1ProteinHetionet hetionet:covaries:10752-117144Inferred only
CATSPER1 covaries with CHTOPProteinHetionet hetionet:covaries:117144-26097Inferred only
FFAR3 covaries with CATSPER1ProteinHetionet hetionet:covaries:117144-2865Inferred only
ADAMTSL4 interacts with CATSPER1ProteinHetionet hetionet:interacts:117144-54507Inferred only
BEGAIN interacts with CATSPER1ProteinHetionet hetionet:interacts:117144-57596Inferred only
CACNA1I interacts with CATSPER1ProteinHetionet hetionet:interacts:117144-8911Inferred only
CHIC2 interacts with CATSPER1ProteinHetionet hetionet:interacts:117144-26511Inferred only
EFEMP2 interacts with CATSPER1ProteinHetionet hetionet:interacts:117144-30008Inferred only
KRTAP4-12 interacts with CATSPER1ProteinHetionet hetionet:interacts:117144-83755Inferred only
MDFI interacts with CATSPER1ProteinHetionet hetionet:interacts:117144-4188Inferred only
TRIP6 interacts with CATSPER1ProteinHetionet hetionet:interacts:117144-7205Inferred only

Show the remaining 5

CATSPER1 participates in FertilizationPathwayReactome R-HSA-1187000Inferred only
CATSPER1 participates in ReproductionPathwayReactome R-HSA-1474165Inferred only
CATSPER1 participates in Sperm Motility And TaxesPathwayReactome R-HSA-1300642Inferred only
CATSPER1 regulates regulation of cilium beat frequency involved in ciliary motilityBiological processgene ontology Q8NEC5|GO:0060296Inferred only
Ca(2+) is transported by CATSPER1CompoundRhea RHEA:29671Inferred only

Reactions

1 reaction

Ca(2+)Ca(2+)
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data

Other names

1 name

Resolves to: CATSPER1

Also called: hCatSper

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