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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P13497

BMP1

Protein·UNIPROT:P13497

Open in the graph

Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation..

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[Isoform BMP1-3]: Plays an important role in bone repair by acting as a coactivator of BMP7..

Function from UniProtKB (P13497), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

high bone mass osteogenesis imperfecta has a germline basis in BMP1DiseaseGenCC HGNC:1067|MONDO:0017791Inferred only
osteogenesis imperfecta type 13 has a germline basis in BMP1DiseaseGenCC HGNC:1067|MONDO:0013924Inferred only
osteogenesis imperfecta type 3 has a germline basis in BMP1DiseaseGenCC HGNC:1067|MONDO:0009804Inferred only

Statements

33 statements

33 statements · 6 reference databases · Subject: BMP1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, UniProt, WikiPathways

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ADRA1A interacts with BMP1ProteinHetionet hetionet:interacts:148-649Inferred only
BMP1 interacts with CHRDProteinHetionet hetionet:interacts:649-8646Inferred only
BMP1 interacts with DMP1ProteinHetionet hetionet:interacts:1758-649Inferred only
BMP1 interacts with GEMProteinHetionet hetionet:interacts:2669-649Inferred only
BMP1 interacts with PCOLCEProteinHetionet hetionet:interacts:5118-649Inferred only
BMP1 interacts with TP53ProteinHetionet hetionet:interacts:649-7157Inferred only
BMP1 participates in 8p23 1 copy number variation syndromePathwayWikiPathways WP5346Inferred only
BMP1 participates in AdipogenesisPathwayWikiPathways WP236Inferred only
BMP1 participates in Anchoring fibril formationPathwayReactome R-HSA-2214320Inferred only
BMP1 participates in Assembly of collagen fibrils and other multimeric structuresPathwayReactome R-HSA-2022090Inferred only
BMP1 participates in Canonical and non canonical TGF B signalingPathwayWikiPathways WP3874Inferred only
BMP1 participates in Cardiac progenitor differentiationPathwayWikiPathways WP2406Inferred only

Show the remaining 21

BMP1 participates in Collagen biosynthesis and modifying enzymesPathwayReactome R-HSA-1650814Inferred only
BMP1 participates in Collagen formationPathwayReactome R-HSA-1474290Inferred only
BMP1 participates in Crosslinking of collagen fibrilsPathwayReactome R-HSA-2243919Inferred only
BMP1 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
BMP1 participates in EDA signaling in hair follicle developmentPathwayWikiPathways WP3930Inferred only
BMP1 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
BMP1 participates in Metabolic pathways of fibroblastsPathwayWikiPathways WP5312Inferred only
BMP1 participates in Oligodendrocyte developmentPathwayWikiPathways WP5574Inferred only
BMP1 participates in Type I collagen synthesis in the context of osteogenesis imperfectaPathwayWikiPathways WP4786Inferred only
BMP1 regulates positive regulation of cartilage developmentBiological processgene ontology P13497|GO:0061036Inferred only
CREG1 increases the expression of BMP1ProteinHetionet hetionet:regulates:8804-649Inferred only
HNF4A increases the expression of BMP1ProteinHetionet hetionet:regulates:3172-649Inferred only
BMP1 requires the cofactor Zn(2+)CompoundUniProt P13497Inferred only
Ala-tRNA(Ala) is a substrate of BMP1CompoundHuman-GEM MAR05166Inferred only
Asn-tRNA(Asn) is a substrate of BMP1CompoundHuman-GEM MAR05166Inferred only
Asp-tRNA(Asp) is a substrate of BMP1CompoundHuman-GEM MAR05166Inferred only
Gln-tRNA(Gln) is a substrate of BMP1CompoundHuman-GEM MAR05166Inferred only
Gly-tRNA(Gly) is a substrate of BMP1CompoundHuman-GEM MAR05166Inferred only
Met-tRNA(Met) is a substrate of BMP1CompoundHuman-GEM MAR05166Inferred only
Phe-tRNA(Phe) is a substrate of BMP1CompoundHuman-GEM MAR05166Inferred only
Trp-tRNA(Trp) is a substrate of BMP1CompoundHuman-GEM MAR05166Inferred only

Reactions

1 reaction

801ATP+11Gly-tRNA(Gly)+802water+23Ala-tRNA(Ala)+17MAM02340c+5Asn-tRNA(Asn)+16Asp-tRNA(Asp)+19Gln-tRNA(Gln)+30MAM02377c+6MAM02380c+41MAM02404c+22MAM02405c+4Met-tRNA(Met)+8Phe-tRNA(Phe)+10MAM02415c

Other names

6 names

Resolves to: BMP1

Also called: BMP-1Mammalian tolloid proteinmTldPCOLCPCPProcollagen C-proteinase

← Every protein Find it in the graph →

+16MAM02416c

+12MAM02419c

+5Trp-tRNA(Trp)

+7MAM02421c

+15MAM02423c

→

801ADP

+MAM01350c

+801phosphate(3-)

+23MAM03063c

+17MAM03064c

+5MAM03065c

+16MAM03066c

+19MAM03068c

+30MAM03069c

+11MAM03070c

+6MAM03071c

+41MAM03073c

+22MAM03074c

+4MAM03075c

+8MAM03076c

+10MAM03077c

+16MAM03078c

+12MAM03079c

+5MAM03080c

+7MAM03081c

+15MAM03082c

Catalysed by BMP1

Reaction pageLeft to rightBalance undeterminableEC 3.4.24.19cytosol

Human-GEM MAR05166CC BY 4.0Reference data