Proteins/UNIPROT:P41238

APOBEC1

ProteinUNIPROT:P41238

Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs. Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity)..

Function from UniProtKB (P41238), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 4 reference databases · Subject: APOBEC1 · Sources: gene ontology, Hetionet, Reactome, UniProt

Order

APOBEC1 covaries with C1orf74ProteinHetionet hetionet:covaries:148304-339Inferred only
OR8B4 covaries with APOBEC1ProteinHetionet hetionet:covaries:283162-339Inferred only
APOBEC1 interacts with A1CFProteinHetionet hetionet:interacts:29974-339Inferred only
APOBEC1 interacts with APOBEC2ProteinHetionet hetionet:interacts:10930-339Inferred only
APOBEC1 interacts with BAG4ProteinHetionet hetionet:interacts:339-9530Inferred only
APOBEC1 interacts with CELF2ProteinHetionet hetionet:interacts:10659-339Inferred only
APOBEC1 interacts with DNAJB11ProteinHetionet hetionet:interacts:339-51726Inferred only
APOBEC1 interacts with KPNA2ProteinHetionet hetionet:interacts:339-3838Inferred only
APOBEC1 participates in Formation of the EditosomePathwayReactome R-HSA-75094Inferred only
APOBEC1 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
APOBEC1 participates in mRNA EditingPathwayReactome R-HSA-75072Inferred only
APOBEC1 participates in mRNA Editing: C to U ConversionPathwayReactome R-HSA-72200Inferred only

Show the remaining 3

APOBEC1 regulates negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decayBiological processgene ontology P41238|GO:2000623Inferred only
APOBEC1 regulates positive regulation of gene expression via chromosomal CpG island demethylationBiological processgene ontology P41238|GO:0044029Inferred only
APOBEC1 requires the cofactor Zn(2+)CompoundUniProt P41238Inferred only

Reactions

2 reactions

CHEBI:82748+water+hydronCHEBI:65315+ammonium
Catalysed by APOBEC1 or APOBEC2
Reaction pageLeft to rightBalanced
Rhea RHEA:21772CC BY 4.0Reference data
a cytidine in mRNA+water+hydrona uridine in mRNA+ammonium
Catalysed by APOBEC1
Reaction pageLeft to rightBalance undeterminable

Other names

6 names

Resolves to: APOBEC1

Also called: APO1APOBEC-1Apolipoprotein B mRNA-editing enzyme 1Apolipoprotein B mRNA-editing enzyme catalytic subunit 1HEPRmRNA(cytosine(6666)) deaminase 1

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