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Proteins/UNIPROT:Q96PC3

AP1S3

Protein·UNIPROT:Q96PC3

Open in the graph

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking..

Function from UniProtKB (Q96PC3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

palmoplantar pustulosis has a germline basis in AP1S3DiseaseGenCC HGNC:18971|MONDO:0015597Inferred only
psoriasis 14, pustular has a germline basis in AP1S3DiseaseGenCC HGNC:18971|MONDO:0013626Inferred only
psoriasis 15, pustular, susceptibility to has a germline basis in AP1S3DiseaseGenCC HGNC:18971|MONDO:0014494Inferred only

Statements

19 statements

19 statements · 2 reference databases · Subject: AP1S3 · Sources: Hetionet, Reactome

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AP1S3 covaries with MMP17ProteinHetionet hetionet:covaries:130340-4326Inferred only
PRKAG1 interacts with AP1S3ProteinHetionet hetionet:interacts:130340-5571Inferred only
UBC interacts with AP1S3ProteinHetionet hetionet:interacts:130340-7316Inferred only
AP1S3 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
AP1S3 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
AP1S3 participates in Golgi Associated Vesicle BiogenesisPathwayReactome R-HSA-432722Inferred only
AP1S3 participates in HIV InfectionPathwayReactome R-HSA-162906Inferred only
AP1S3 participates in Host Interactions of HIV factorsPathwayReactome R-HSA-162909Inferred only
AP1S3 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
AP1S3 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
AP1S3 participates in Lysosome Vesicle BiogenesisPathwayReactome R-HSA-432720Inferred only
AP1S3 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only

Show the remaining 7

AP1S3 participates in MHC class II antigen presentationPathwayReactome R-HSA-2132295Inferred only
AP1S3 participates in Nef mediated downregulation of MHC class I complex cell surface expressionPathwayReactome R-HSA-164940Inferred only
AP1S3 participates in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adaptersPathwayReactome R-HSA-164938Inferred only
AP1S3 participates in The role of Nef in HIV-1 replication and disease pathogenesisPathwayReactome R-HSA-164952Inferred only
AP1S3 participates in trans-Golgi Network Vesicle BuddingPathwayReactome R-HSA-199992Inferred only
AP1S3 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
AP1S3 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only

Other names

7 names

Resolves to: AP1S3

Also called: Adaptor protein complex AP-1 subunit sigma-1CAdaptor-related protein complex 1 subunit sigma-1CClathrin assembly protein complex 1 sigma-1C small chainGolgi adaptor HA1/AP1 adaptin sigma-1C subunitSigma 1C subunit of AP-1 clathrinSigma-adaptin 1CSigma1C-adaptin

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