psoriasis 14, pustular
MONDO:0013626Mondo
Findings
No curated finding names psoriasis 14, pustular yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any psoriasis in which the cause of the disease is a mutation in the IL36RN gene.
Definition from the Mondo Disease Ontology (MONDO:0013626), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal recessive inheritance
- Onset and course
- Infantile onset · Juvenile onset · Neonatal onset · Young adult onset · Childhood onset
HPO, annotations 2026-09-02
Features
15 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Elevated circulating C-reactive protein concentrationHPOHP:0011227
- 30 of 30 reported patients
- Epidermal acanthosisHPOHP:0025092
- 8 of 8 reported patients
- Increased total leukocyte countHPOHP:0001974
- 16 of 16 reported patients
- Increased total neutrophil countHPOHP:0011897
- 14 of 14 reported patients
- ParakeratosisHPOHP:0001036
- 8 of 8 reported patients
- Psoriasiform dermatitisHPOHP:0003765
- 16 of 16 reported patients
- 14 of 14 reported patients · Adult onset
Show the remaining 3
- ErythemaHPOHP:0010783
- FeverHPOHP:0001945
- PustuleHPOHP:0200039
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- IL36RNHGNC:15561
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal recessive · 2021
- Strong · Genomics England PanelApp · Autosomal recessive · 2020
- Supportive · Orphanet · Autosomal recessive · 2021
- Supportive · Orphanet · Autosomal recessive · 2021
- Supportive · Orphanet · Autosomal recessive · 2021
- Limited · G2P · Autosomal recessive · 2025
- AP1S3HGNC:18971
- Supportive · Orphanet · Autosomal recessive · 2021
- Supportive · Orphanet · Autosomal recessive · 2021
Where it sits
Other names
12 names
Resolves to: psoriasis 14, pustular
- Also called
- acrodermatitis continua of Hallopeauacrodermatitis continua suppurativa of Hallopeaudeficiency of IL-36R antagonistdeficiency of IL-36Radeficiency of the interleukin-36 receptor antagonistDITRAfamilial generalised pustular psoriasisIL36RN psoriasisInterleukin 36 receptor antagonist deficiencypsoriasis caused by mutation in IL36RNPSORPPSORS14