Proteins/UNIPROT:Q96BT7

ALKBH8

ProteinUNIPROT:Q96BT7tRNA

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis..

Function from UniProtKB (Q96BT7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

autosomal recessive non-syndromic intellectual disability has a germline basis in ALKBH8DiseaseGenCC HGNC:25189|MONDO:0019502Inferred only
intellectual developmental disorder, autosomal recessive 71 has a germline basis in ALKBH8DiseaseGenCC HGNC:25189|MONDO:0032789Inferred only

Statements

5 statements

5 statements · 3 reference databases · Subject: ALKBH8 · Sources: Hetionet, Reactome, UniProt

Order

ALKBH8 covaries with TASOR2ProteinHetionet hetionet:covaries:54906-91801Inferred only
ALKBH8 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
ALKBH8 participates in tRNA modification in the nucleus and cytosolPathwayReactome R-HSA-6782315Inferred only
ALKBH8 participates in tRNA processingPathwayReactome R-HSA-72306Inferred only
ALKBH8 requires the cofactor iron(2+)CompoundUniProt Q96BT7Inferred only

Reactions

1 reaction

CHEBI:74882+S-adenosyl-L-methionineCHEBI:74851+S-adenosyl-L-homocysteine
Catalysed by ALKBH8
Reaction pageDirection not assertedBalanced
Rhea RHEA:43208CC BY 4.0Reference data

Other names

5 names

Resolves to: ALKBH8

Also called: ABH8Alkylated DNA repair protein alkB homolog 8Alpha-ketoglutarate-dependent dioxygenase ALKBH8carboxymethyluridine(34)-5-OS-adenosyl-L-methionine-dependent tRNA methyltransferase ALKBH8

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