Loading the page.
Proteins/UNIPROT:Q9GZX7
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation..
Function from UniProtKB (Q9GZX7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
42 statements
42 statements · 6 reference databases · Subject: AICDA · Sources: gene ontology, Hetionet, Human-GEM, Reactome, UniProt, WikiPathways
5 reactions
2'-deoxycytidine+water2'-deoxyuridine+ammonium
Reaction pageLeft to rightBalancedEC 3.5.4.5cytosol
Human-GEM MAR04514CC BY 4.0Reference data
3 names
Resolves to: AICDA
Reaction pageLeft to rightBalancedEC 3.5.4.5cytosol
Human-GEM MAR04580CC BY 4.0Reference data
cytidine+waterammonium+uridine
Catalysed by AICDA
Reaction pageLeft to rightBalancedEC 3.5.4.5nucleus
Human-GEM MAR08446CC BY 4.0Reference data
2'-deoxycytidine+water2'-deoxyuridine+ammonium
Catalysed by AICDA
Reaction pageLeft to rightBalancedEC 3.5.4.5nucleus
Human-GEM MAR08480CC BY 4.0Reference data
a 2'-deoxycytidine in single-stranded DNA+water+hydrona 2'-deoxyuridine in single-stranded DNA+ammonium
Catalysed by APOBEC3A or APOBEC3H or APOBEC3F or APOBEC3D or AICDA or APOBEC3G or APOBEC3C or APOBEC3B
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50948CC BY 4.0Reference data