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Proteins/UNIPROT:P31941
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation..
Function from UniProtKB (P31941), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 statements
2 statements · 1 reference database · Subject: APOBEC3A · Sources: Hetionet
1 reaction
a 2'-deoxycytidine in single-stranded DNA+water+hydrona 2'-deoxyuridine in single-stranded DNA+ammonium
Catalysed by APOBEC3A or APOBEC3H or APOBEC3F or APOBEC3D or AICDA or APOBEC3G or APOBEC3C or APOBEC3B
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50948CC BY 4.0Reference data
2 names
Resolves to: APOBEC3A