Proteins/UNIPROT:Q9UHX3

ADGRE2

ProteinUNIPROT:Q9UHX3

Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Probably signals through G proteins. Is a regulator of mast cell degranulation..

Function from UniProtKB (Q9UHX3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

autosomal dominant vibratory urticaria has a germline basis in ADGRE2DiseaseGenCC HGNC:3337|MONDO:0007447Inferred only

Statements

23 statements

23 statements · 4 reference databases · Subject: ADGRE2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ACOX2 covaries with ADGRE2ProteinHetionet hetionet:covaries:30817-8309Inferred only
DKK4 covaries with ADGRE2ProteinHetionet hetionet:covaries:27121-30817Inferred only
EDAR covaries with ADGRE2ProteinHetionet hetionet:covaries:10913-30817Inferred only
ADGRE2 covaries with ICAM3ProteinHetionet hetionet:covaries:30817-3385Inferred only
ADGRE2 covaries with MPEG1ProteinHetionet hetionet:covaries:219972-30817Inferred only
ADGRE2 covaries with PNPProteinHetionet hetionet:covaries:30817-4860Inferred only
ADGRE2 covaries with PRR11ProteinHetionet hetionet:covaries:30817-55771Inferred only
ADGRE2 covaries with PTPRJProteinHetionet hetionet:covaries:30817-5795Inferred only
ADGRE2 covaries with SERPING1ProteinHetionet hetionet:covaries:30817-710Inferred only
SLC66A3 covaries with ADGRE2ProteinHetionet hetionet:covaries:130814-30817Inferred only
ADGRE2 covaries with ST14ProteinHetionet hetionet:covaries:30817-6768Inferred only
ADGRE2 covaries with TACSTD2ProteinHetionet hetionet:covaries:30817-4070Inferred only

Show the remaining 11

TREML2 covaries with ADGRE2ProteinHetionet hetionet:covaries:30817-79865Inferred only
TXLNB covaries with ADGRE2ProteinHetionet hetionet:covaries:167838-30817Inferred only
ZNF133 covaries with ADGRE2ProteinHetionet hetionet:covaries:30817-7692Inferred only
UBC interacts with ADGRE2ProteinHetionet hetionet:interacts:30817-7316Inferred only
ADGRE2 participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
ADGRE2 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
ADGRE2 participates in GPCRs class B secretin likePathwayWikiPathways WP334Inferred only
ADGRE2 participates in GPCRs otherPathwayWikiPathways WP117Inferred only
ADGRE2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ADGRE2 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
ADGRE2 regulates regulation of mast cell degranulationBiological processgene ontology Q9UHX3|GO:0043304Inferred only

Other names

4 names

Resolves to: ADGRE2

Also called: CD antigen CD312EGF-like module receptor 2EGF-like module-containing mucin-like hormone receptor-like 2EMR2

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