Loading the page.
Proteins/UNIPROT:Q8TDX5
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolinate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway..
Function from UniProtKB (Q8TDX5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
12 statements
12 statements · 7 reference databases · Subject: ACMSD · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde+protonMAM00633c+carbon dioxide
Catalysed by ACMSD
Reaction pageLeft to rightBalancedEC 4.1.1.45cytosol
Human-GEM MAR04231CC BY 4.0Reference data
(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde+hydronCHEBI:77634+carbon dioxide
Catalysed by ACMSD
Reaction pageLeft to rightBalanced
1 name
Resolves to: ACMSD