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Proteins/UNIPROT:Q0P651
Catalyzes the hydrolysis of an acyl chain from the tetra-acylated cardiolipin (CL) and produces the tri-acylated monolysocardiolipin (MLCL). Prefers CL with shorter and saturated fatty acyl chains as substrates. Together with Tafazzin (TAZ), it participates in the mechanism of CL remodeling, a process consisting of repetitive cycles of hydrolysis and reacylation of the fatty acids that make up CL, where the nascent acyl chains are replaced with longer, unsaturated chains..
Function from UniProtKB (Q0P651), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 statements
5 statements · 2 reference databases · Subject: ABHD18 · Sources: Hetionet, Rhea
1 reaction
a cardiolipin+water1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol+a fatty acid+hydron
Catalysed by ABHD18
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32935CC BY 4.0Reference data
3 names
Resolves to: ABHD18