Pathway
TRAF3-dependent IRF activation pathway
MAVS via its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the signaling complex. TRAF3 acts as a scaffold for the assembly of a signaling complex composed of IKK epsilon/TBK1, leading to the activation of transcription factors IRF3/IRF7.
REACT:R-HSA-918233Reactome
What the reference databases state
Statements
15 statements
15 statements · 1 reference database · Subject: TRAF3-dependent IRF activation pathway · Sources: Reactome
- CREBBP participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- EP300 participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- IFIH1 participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- IFNB1 participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- IKBKE participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- IRF3 participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- IRF7 participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- MAVS participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- RIGI participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- RNF135 participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- SIKE1 participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- TBK1 participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
Show the remaining 3
- TRAF3 participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- TRIM25 participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only
- TRIM4 participates in TRAF3-dependent IRF activation pathwayProteinReactome R-HSA-918233Inferred only