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Proteins/UNIPROT:Q9BRV8
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex. The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth..
Function from UniProtKB (Q9BRV8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
22 statements
22 statements · 4 reference databases · Subject: SIKE1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
3 names
Resolves to: SIKE1