Proteins/UNIPROT:Q9C037

TRIM4

ProteinUNIPROT:Q9C037

E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor RIGI, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction..

Function from UniProtKB (Q9C037), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

28 statements

28 statements · 3 reference databases · Subject: TRIM4 · Sources: gene ontology, Hetionet, Reactome

Order

MDM2 interacts with TRIM4ProteinHetionet hetionet:interacts:4193-89122Inferred only
SUMO1 interacts with TRIM4ProteinHetionet hetionet:interacts:7341-89122Inferred only
TRIM4 interacts with TRIM41ProteinHetionet hetionet:interacts:89122-90933Inferred only
UBC interacts with TRIM4ProteinHetionet hetionet:interacts:7316-89122Inferred only
UBD interacts with TRIM4ProteinHetionet hetionet:interacts:10537-89122Inferred only
TRIM4 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
TRIM4 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
TRIM4 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
TRIM4 participates in DDX58/IFIH1-mediated induction of interferon-alpha/betaPathwayReactome R-HSA-168928Inferred only
TRIM4 participates in DeubiquitinationPathwayReactome R-HSA-5688426Inferred only
TRIM4 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
TRIM4 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only

Show the remaining 16

TRIM4 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
TRIM4 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
TRIM4 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
TRIM4 participates in Negative regulators of DDX58/IFIH1 signalingPathwayReactome R-HSA-936440Inferred only
TRIM4 participates in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10PathwayReactome R-HSA-933543Inferred only
TRIM4 participates in Ovarian tumor domain proteasesPathwayReactome R-HSA-5689896Inferred only
TRIM4 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
TRIM4 participates in SARS-CoV InfectionsPathwayReactome R-HSA-9679506Inferred only
TRIM4 participates in SARS-CoV-2 activates/modulates innate and adaptive immune responsesPathwayReactome R-HSA-9705671Inferred only
TRIM4 participates in SARS-CoV-2 InfectionPathwayReactome R-HSA-9694516Inferred only
TRIM4 participates in SARS-CoV-2-host interactionsPathwayReactome R-HSA-9705683Inferred only
TRIM4 participates in TRAF3-dependent IRF activation pathwayPathwayReactome R-HSA-918233Inferred only
TRIM4 participates in TRAF6 mediated IRF7 activationPathwayReactome R-HSA-933541Inferred only
TRIM4 participates in TRAF6 mediated NF-kB activationPathwayReactome R-HSA-933542Inferred only
TRIM4 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
TRIM4 regulates regulation of gene expressionBiological processgene ontology Q9C037|GO:0010468Inferred only

Other names

4 names

Resolves to: TRIM4

Also called: RING finger protein 87RING-type E3 ubiquitin transferase TRIM4RNF87Tripartite motif-containing protein 4

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