Pathway
Synthesis of PG
Phosphatidylglycerol (PG) is synthesised at the inner mitochondrial (IM) membrane, phosphatidic acid (PA) and cytidine triphosphate (CTP) are converted into cytidine diphosphate-diacylglycerol (CDP-DAG), which in turn is converted with glycerol-3-phosphate (G3P) into phosphatidylglycerophosphate (PGP) and cytidine monophosphate (CMP). Finally, PGP is dephosphorylated to PG. In addition, PG can be synthesised at the endoplamic reticulum (ER) membrane when phospholipase D transphosphatidylates phosphatidylcholine (PC) with glycerol to displace choline (Cho) and form PG.
REACT:R-HSA-1483148Reactome
What the reference databases state
Statements
8 statements
8 statements · 1 reference database · Subject: Synthesis of PG · Sources: Reactome
- CDS2 participates in Synthesis of PGProteinReactome R-HSA-1483148Inferred only
- PGS1 participates in Synthesis of PGProteinReactome R-HSA-1483148Inferred only
- PLD1 participates in Synthesis of PGProteinReactome R-HSA-1483148Inferred only
- PLD2 participates in Synthesis of PGProteinReactome R-HSA-1483148Inferred only
- PLD3 participates in Synthesis of PGProteinReactome R-HSA-1483148Inferred only
- PLD4 participates in Synthesis of PGProteinReactome R-HSA-1483148Inferred only
- PLD6 participates in Synthesis of PGProteinReactome R-HSA-1483148Inferred only
- PTPMT1 participates in Synthesis of PGProteinReactome R-HSA-1483148Inferred only