Pathway
Suppression of phagosomal maturation
The fate of phagosomes is usually directed by factors in the host phagocyte and involves flooding itself with superoxide, nitric oxide, and protons. Acidification is the prerequisite for later fusion with a lysosome. Mycobacterium tuberculosis (Mtb) releases substances that inhibit all of these processes, effectively arresting the phagosome in the present state and creating a protected niche for Mtb multiplication.
REACT:R-HSA-9637687Reactome
What the reference databases state
Statements
13 statements
13 statements · 1 reference database · Subject: Suppression of phagosomal maturation · Sources: Reactome
- ATP6V1H participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
- CORO1A participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
- HGS participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
- KPNA1 participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
- KPNB1 participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
- NOS2 participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
- RAB5A participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
- RAB7A participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
- RPS27A participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
- UBA52 participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
- UBB participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
- UBC participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only
Show the remaining 1
- VPS33B participates in Suppression of phagosomal maturationProteinReactome R-HSA-9637687Inferred only