Proteins/UNIPROT:Q9Y241

HIGD1A

ProteinUNIPROT:Q9Y241

Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes..

Function from UniProtKB (Q9Y241), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 4 reference databases · Subject: HIGD1A · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

MYC interacts with HIGD1AProteinHetionet hetionet:interacts:25994-4609Inferred only
UBC interacts with HIGD1AProteinHetionet hetionet:interacts:25994-7316Inferred only
HIGD1A participates in Aerobic respiration and respiratory electron transportPathwayReactome R-HSA-1428517Inferred only
HIGD1A participates in Cellular response to hypoxiaPathwayReactome R-HSA-1234174Inferred only
HIGD1A participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
HIGD1A participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
HIGD1A participates in Complex IV assemblyPathwayReactome R-HSA-9864848Inferred only
HIGD1A participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
HIGD1A participates in Mitochondrial complex IV assemblyPathwayWikiPathways WP4922Inferred only
HIGD1A participates in Regulation of gene expression by Hypoxia-inducible FactorPathwayReactome R-HSA-1234158Inferred only
HIGD1A participates in Respiratory electron transportPathwayReactome R-HSA-611105Inferred only
HIGD1A regulates negative regulation of apoptotic processBiological processgene ontology Q9Y241|GO:0043066Inferred only

Show the remaining 7

FADD increases the expression of HIGD1AProteinHetionet hetionet:regulates:8772-25994Inferred only
GFOD1 decreases the expression of HIGD1AProteinHetionet hetionet:regulates:54438-25994Inferred only
MSH6 decreases the expression of HIGD1AProteinHetionet hetionet:regulates:2956-25994Inferred only
NFATC3 decreases the expression of HIGD1AProteinHetionet hetionet:regulates:4775-25994Inferred only
SNAI2 decreases the expression of HIGD1AProteinHetionet hetionet:regulates:6591-25994Inferred only
UBE2C increases the expression of HIGD1AProteinHetionet hetionet:regulates:11065-25994Inferred only
USP22 decreases the expression of HIGD1AProteinHetionet hetionet:regulates:23326-25994Inferred only

Other names

4 names

Resolves to: HIGD1A

Also called: HIG1Hypoxia-inducible gene 1 proteinRCF1 homolog ARCF1a

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