Pathway
Evasion by RSV of host interferon responses
Infection with human respiratory syncytial virus (hRSV) is typically associated with low to undetectable levels of type I interferons (IFNs). Several hRSV proteins interact with host innate immune system factors that support the type I interferon response. Nonstructural proteins NS1 and NS2 localize to mitochondria and nucleus where they bind MAVS, DDX58, TRIM25, IRF3, and CREBBP, affecting DDX58/IFIH1-mediated interferon induction (reviewed by Thornhill & Verhoeven, 2020). Additionally, hRSV nucleoprotein interacts with MDA5 downregulating the interferon response and with PKR (EIF2AK2) blocking the innate immune system signal for shutting down protein translation. Further interactions of the M, SH, and G proteins are reviewed by van Royen et al, 2022.
What the reference databases state
Statements
32 statements
32 statements · 1 reference database · Subject: Evasion by RSV of host interferon responses · Sources: Reactome
- CREBBP participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- CUL5 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- EIF2AK2 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- ELOB participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- ELOC participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- EP300 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFIH1 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNA1 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNA10 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNA14 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNA16 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNA2 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
Show the remaining 20
- IFNA21 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNA4 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNA5 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNA6 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNA7 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNA8 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNAR1 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IFNB1 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- IRF3 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- JAK1 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- MAVS participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- RBX1 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- RIGI participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- RPS27A participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- STAT2 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- TRIM25 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- TYK2 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- UBA52 participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- UBB participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only
- UBC participates in Evasion by RSV of host interferon responsesProteinReactome R-HSA-9833109Inferred only