N-acetyl-D-glucosamine 6-phosphate

Three steps

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 4 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 6 morecytosol, extracellular space, mitochondrial matrix