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Catalyst

carnosineFinding

Carnosine increases depression remission rate

raisesVery limited evidenceFinding

01 · The sentence it was drawn from

“Patients in the L-Carnosine group experienced significantly greater response and remission rate than the placebo group [Ps = 0.023 and 0.012; respectively].”
Quoted verbatim from L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind, placebo-controlled trial.
This finding among the 2 findings on its endpoint

carnosine

Depression remission rate

raises

Who
Adults with major depressive disorder (DSM-V, HAM-D 19 or higher), all taking citalopram up to 40 mg/day in both arms
Dose studied
400 mg L-Carnosine twice daily plus citalopram versus placebo plus citalopram, 6 weeks

Very limited evidencePMID 32063564 · 2020

02 · The study

Study
RCT
Duration
6 weeks

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limitedthis finding
  • insufficient

03 · The paper

Journal of affective disorders
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M71R3NG8WHZWFV9MV6EKXVPP