Fructo-oligosaccharides has no detected effect on glycated haemoglobin (HbA1c)

no difference foundModerate evidenceFinding

01 · The sentence it was drawn from

“No significant difference was observed between scFOS and placebo in the change of HbA1c from V2 to V5 (+0.055% vs +0.030%, p = 0.6835) in the ITT population.”

Quoted verbatim from Targeting gut microbiota with short-chain fructo-oligosaccharides prebiotic fibers to support metabolic health in overweight prediabetic adults: a randomized, double-blinded, placebo-controlled study.

This finding among the 64 findings on its endpoint

fructo-oligosaccharides

Glycated haemoglobin (HbA1c)

no difference found

Who: Overweight adults with prediabetes (fasting glycaemia 1 to 1.25 g/L), intention-to-treat population, placebo maltodextrin
Dose studied: 20 g/day (two 10 g sachets) for 12 weeks

Moderate evidencePMID 41479657 · 2025

02 · The study

Study: RCT
Duration: 3 months

Evidence, by strength

strong
moderatethis finding
limited
very limited
insufficient

03 · The paper

Frontiers in nutrition

Targeting gut microbiota with short-chain fructo-oligosaccharides prebiotic fibers to support metabolic health in overweight prediabetic adults: a randomized, double-blinded, placebo-controlled study.

2025PMID 41479657doi 10.3389/fnut.2025.1718169An author is affiliated with a producer

What else it reported2 findings · 0 compounds · 2 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M71GZJAPNHX5EQDASG4JRVXF