PapersPMID:41479657
Targeting gut microbiota with short-chain fructo-oligosaccharides prebiotic fibers to support metabolic health in overweight prediabetic adults: a randomized, double-blinded, placebo-controlled study.
- findings
- 2
- compound
- 1
- endpoints
- 2
- no difference found
- 1
- Study, every finding
- RCT · 3 months
- Dose studied, every finding
- 20 g/day (two 10 g sachets) for 12 weeks
What moved
How to read these marks →- Decreases fat mass
moderate
“Body fat mass decreased in the scFOS arm while it increased in the placebo arm between V2 and V5.”
- Interests
- An author is affiliated with a producer
- Population
- Overweight adults with prediabetes, intention-to-treat population, fat mass by DEXA
What did not
“No significant difference was observed between scFOS and placebo in the change of HbA1c from V2 to V5 (+0.055% vs +0.030%, p = 0.6835) in the ITT population.”
- Interests
- An author is affiliated with a producer
- Population
- Overweight adults with prediabetes (fasting glycaemia 1 to 1.25 g/L), intention-to-treat population, placebo maltodextrin
Study record
- Design
- randomised controlled trial
- Species
- human
- Population
- Overweight adults with prediabetes (fasting glycemia 1 to 1.25 g/L, BMI 23 to 34.9 kg/m2), three clinical units in France; short-chain FOS (Actilight 950P: 1-kestose, nystose, 1F-fructofuranosyl nystose)
- Participants
- 66
- Comparator
- placebo
- Duration
- 84 days
- Endpoints measured
- 50