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Catalyst

CDP-cholineFinding

CDP-choline has no detected effect on all-cause mortality

no difference foundVery limited evidenceFindingreplicated ×1

01 · The sentence it was drawn from

“A pooled analysis of eight trials indicates there may be little or no difference in all-cause mortality comparing citicoline with placebo (17.3% versus 18.5%; RR 0.94, 95% CI 0.83 to 1.07; I² = 0%; low-quality evidence due to risk of bias).”
Quoted verbatim from Citicoline for treating people with acute ischemic stroke.
This finding among the 156 findings on its endpoint

CDP-choline

All-cause mortality

no difference found

Effect as reported

0.94risk ratio

CI 0.83 to 1.07

Who
Adults with acute ischaemic stroke; pooled analysis of eight of ten randomised trials, citicoline given orally, intravenously or both
Dose studied
citicoline 500 mg to 2000 mg per day, oral, intravenous or both

Very limited evidencePMID 32860632 · 2020

02 · The study

Study
meta-analysis
Duration
not reported

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limitedthis finding
  • insufficient

03 · The paper

The Cochrane database of systematic reviews
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M70GX213X51WBX6867HHAH9X