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Catalyst

pyridoxal 5'-phosphateFinding

Pyridoxal 5'-phosphate has no detected effect on serum creatinine concentration

no difference foundInsufficient evidenceFinding

01 · The sentence it was drawn from

“Concomitant treatment with gentamicin and either Ca2+ or pyridoxal-5'-phosphate decreased serum urea level, did not significantly affect serum creatinine concentration, and significantly increased cortical GSH concentration in comparison to the values of these parameters following gentamicin treatment.”
Quoted verbatim from Comparative modulating effects of captopril, diltiazem, dietary calcium and pyridoxal-5'-phosphate on gentamicin-induced nephrotoxicity in the rat.
This finding among the 19 findings on its endpoint

pyridoxal 5'-phosphate

Serum creatinine concentration

no difference found

Who
Rats given gentamicin 80 mg/kg/day intramuscularly for 6 days in all treated groups; pyridoxal-5'-phosphate added in one group, compared with gentamicin alone
Dose studied
not reported

Insufficient evidencePMID 8270187 · 1993

02 · The study

Study
animal · not in humans
Duration
6 days

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limited
  • insufficientthis finding

03 · The paper

General pharmacology
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M705FSNYGWDRF84TT0X5EG8A