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Catalyst

(R)-carnitineFinding

(R)-carnitine has no detected effect on all-cause mortality

no difference foundVery limited evidenceFindingreplicated ×1

01 · The sentence it was drawn from

“Across five enrolled clinical trials, we found that L-carnitine supplementation reduce one-year mortality in septic patients with SOFA> 12 (RR: 0.68; 95% CI: 0.49 to 0.96; P= 0.03) but had no significant effect on reducing 28-day mortality ((RR: 0.93; 95% CI: 0.68 to 1.28; P= 0.65) compared to placebo.”
Quoted verbatim from The Effect of L-Carnitine on Mortality Rate in Septic Patients: A Systematic Review and Meta-Analysis on Randomized Clinical Trials.
This finding among the 156 findings on its endpoint

(R)-carnitine

All-cause mortality

no difference found

Effect as reported

0.93risk ratio

CI 0.68 to 1.28

Who
Septic patients in five randomized trials; 28-day mortality
Dose studied
not reported

Very limited evidencePMID 32718301 · 2021

02 · The study

Study
meta-analysis
Duration
4 weeks

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limitedthis finding
  • insufficient

03 · The paper

Endocrine, metabolic & immune disorders drug targets
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M701EDNRGTZZW68WNWNHJ4QM