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PapersPMID:32718301

The Effect of L-Carnitine on Mortality Rate in Septic Patients: A Systematic Review and Meta-Analysis on Randomized Clinical Trials.

Endocrine, metabolic & immune disorders drug targets2021The record ↗

  1. Finding, very limited evidenceno difference foundAll-cause mortality

No finding here moved its endpoint.

What did not

1 findingHow to read these marks →
  • No detected effect on all-cause mortality

    very limited

    “Across five enrolled clinical trials, we found that L-carnitine supplementation reduce one-year mortality in septic patients with SOFA> 12 (RR: 0.68; 95% CI: 0.49 to 0.96; P= 0.03) but had no significant effect on reducing 28-day mortality ((RR: 0.93; 95% CI: 0.68 to 1.28; P= 0.65) compared to placebo.”
    Study
    meta-analysis
    Duration
    4 weeks
    Effect
    0.93 risk ratio, 95% CI 0.68 to 1.28
    Population
    Septic patients in five randomized trials; 28-day mortality

Study record

Design
meta-analysis
Species
human
Population
septic patients in five randomized clinical trials of L-carnitine
Participants
not reported
Comparator
placebo
Duration
not reported
Endpoints measured
2