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Catalyst

cholineFinding

Choline has no detected effect on incidence of cardiovascular disease (composite)

no difference foundModerate evidenceFindingreplicated ×1

01 · The sentence it was drawn from

“Results of Cox proportional hazard regression indicated no association between dietary energy-adjusted total choline (HR: 0.80; 95% CI: 0.56–1.23) nor energy-adjusted betaine (HR: 0.96; 95% CI: 0.64–1.44) and the incidence of CVD (Table 3).”
Quoted verbatim from Association between dietary choline and betaine intake and 10.6-year cardiovascular disease in adults.
This finding among the 18 findings on its endpoint

choline

Incidence of cardiovascular disease (composite)

no difference found

Effect as reported

0.8hazard ratio

CI 0.56 to 1.23

Who
2606 adults without prior cardiovascular disease in the Tehran Lipid and Glucose Study, median follow-up 10.6 years, 187 incident events; dietary intake by 168-item food-frequency questionnaire
Dose studied
energy-adjusted dietary total choline (sum of free choline, glycerophosphocholine, phosphocholine, phosphatidylcholine and sphingomyelin), tertiles

Moderate evidencePMID 34986852 · 2022

02 · The study

Study
cohort
Duration
not reported

Evidence, by strength

  • strong
  • moderatethis finding
  • limited
  • very limited
  • insufficient

03 · The paper

Nutrition journal
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6ZVJCRB91APMYKBWND5Z5TT