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PapersPMID:34986852

Association between dietary choline and betaine intake and 10.6-year cardiovascular disease in adults.

Nutrition journal2022The record ↗

  1. Finding, moderate evidenceno difference foundIncidence of cardiovascular disease (composite)

No finding here moved its endpoint.

What did not

1 findingHow to read these marks →
  • “Results of Cox proportional hazard regression indicated no association between dietary energy-adjusted total choline (HR: 0.80; 95% CI: 0.56–1.23) nor energy-adjusted betaine (HR: 0.96; 95% CI: 0.64–1.44) and the incidence of CVD (Table 3).”
    Study
    cohort
    Effect
    0.8 hazard ratio, 95% CI 0.56 to 1.23
    Dose studied
    energy-adjusted dietary total choline (sum of free choline, glycerophosphocholine, phosphocholine, phosphatidylcholine and sphingomyelin), tertiles
    Population
    2606 adults without prior cardiovascular disease in the Tehran Lipid and Glucose Study, median follow-up 10.6 years, 187 incident events; dietary intake by 168-item food-frequency questionnaire

Study record

Design
cohort study
Species
human
Population
Adults without prior CVD in the Tehran Lipid and Glucose Study, third wave (2006-2008)
Participants
2,606
Comparator
observational
Duration
3,872 days
Endpoints measured
32