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Catalyst

melatoninFinding

Melatonin decreases LDL cholesterol

lowersInsufficient evidenceFindingreplicated ×1

01 · The sentence it was drawn from

“In addition, HFD‐induced increases in the levels of total cholesterol (TC), triglyceride (TG) and low‐density lipoprotein cholesterol (LDL‐C) in serum were reduced by MLT (Figure S2B, p < 0.05).”
Quoted verbatim from Melatonin Mitigates Sarcopenic Obesity via Microbiota and Short-Chain Fatty Acids: Evidence From Epidemiologic and In Vivo Studies.
This finding among the 103 findings on its endpoint

melatonin

LDL cholesterol

lowers

Who
12-month-old female Sprague-Dawley rats fed a high-fat diet (HFD) for 16 weeks, melatonin versus vehicle in HFD-fed rats; serum after overnight fast
Dose studied
10 mg/kg melatonin daily by oral administration, 16 weeks

Insufficient evidencePMID 40511533 · 2025

02 · The study

Study
animal · not in humans
Duration
4 months

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limited
  • insufficientthis finding

03 · The paper

Journal of cachexia, sarcopenia and muscle
What else it reported2 findings · 1 compound · 2 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6ZV2SMJ757KGNNYQ60NDZ6N