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Catalyst

melatoninFinding

Melatonin decreases body weight gain over a feeding or growth period

lowersInsufficient evidenceFinding

01 · The sentence it was drawn from

“HFD significantly increased the body weight of rats, whereas HFD‐induced body weight gain was reduced by MLT (Figure S1C, p < 0.05).”
Quoted verbatim from Melatonin Mitigates Sarcopenic Obesity via Microbiota and Short-Chain Fatty Acids: Evidence From Epidemiologic and In Vivo Studies.
This finding among the 6 findings on its endpoint

melatonin

Body weight gain over a feeding or growth period

lowers

Who
12-month-old female Sprague-Dawley rats fed a high-fat diet (HFD) for 16 weeks, melatonin (MLT) versus vehicle in HFD-fed rats; a normal-diet control group was also housed
Dose studied
10 mg/kg melatonin daily by oral administration, 16 weeks

Insufficient evidencePMID 40511533 · 2025

02 · The study

Study
animal · not in humans
Duration
4 months

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limited
  • insufficientthis finding

03 · The paper

Journal of cachexia, sarcopenia and muscle
What else it reported2 findings · 1 compound · 2 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6ZV2RZ1XMJK32JNN0KFK0Q8