Skip to content
Catalyst

theobromineFinding

Theobromine increases HDL cholesterol

raisesLimited evidenceFinding

01 · The sentence it was drawn from

“Four weeks theobromine supplementation did not affect fasting cholesterol efflux capacity (+0.4 percentage point (pp); 95% CI: −2.81, 3.57; p = 0.81), but significantly increased HDL‐C concentrations (+0.04 mmol L−1; 95% CI: 0.003, 0.07; p < 0.05).”
Quoted verbatim from Theobromine Does Not Affect Fasting and Postprandial HDL Cholesterol Efflux Capacity, While It Decreases Fasting miR-92a Levels in Humans.
This finding among the 93 findings on its endpoint

theobromine

HDL cholesterol

raises

Effect as reported

0.04mean difference

CI 0.003 to 0.07

Who
Overweight and obese healthy men and women with HDL-C below the 50th percentile of the Dutch population; fasting values after 4 weeks of each treatment period
Dose studied
500 mg theobromine per day for 4 weeks versus placebo, randomised double-blind crossover

Limited evidencePMID 29797695 · 2018

02 · The study

Study
crossover
Duration
4 weeks

Evidence, by strength

  • strong
  • moderate
  • limitedthis finding
  • very limited
  • insufficient

03 · The paper

Molecular nutrition & food research
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6ZFKQ0R107AM1Q7JBNM8FP8