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all-cis-5,8,11,14,17-icosapentaenoic acidFinding

All-cis‑5,8,11,14,17-icosapentaenoic acid increases total cholesterol (TC)

raisesModerate evidenceFinding

01 · The sentence it was drawn from

“Subsequent linear mixed models revealed that this effect consisted of a relative increase in HDL and total cholesterol concentration in the EPA-group (table 2).”
Quoted verbatim from Biological effects of add-on eicosapentaenoic acid supplementation in diabetes mellitus and co-morbid depression: a randomized controlled trial.
This finding among the 116 findings on its endpoint

all-cis-5,8,11,14,17-icosapentaenoic acid

Total cholesterol (TC)

raises

Who
Adults aged 18 to 75 with diabetes mellitus (type 1 or 2) and comorbid major depressive disorder, all taking antidepressant medication; 24 analysed
Dose studied
1 g/day fish oil containing more than 90% ethyl-ester EPA (two 500 mg capsules daily) for 12 weeks, versus rapeseed oil and medium chain triglycerides placebo, added to antidepressant therapy

Moderate evidencePMID 23209576 · 2012

02 · The study

Study
RCT
Duration
3 months

Evidence, by strength

  • strong
  • moderatethis finding
  • limited
  • very limited
  • insufficient

03 · The paper

PloS one
What else it reported2 findings · 1 compound · 2 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6ZDNAPVVGY9PVTYATNP80NF