PapersPMID:23209576
Biological effects of add-on eicosapentaenoic acid supplementation in diabetes mellitus and co-morbid depression: a randomized controlled trial.
- findings
- 2
- compound
- 1
- endpoints
- 2
all-cis-5,8,11,14,17-icosapentaenoic acid- Study, every finding
- RCT · 3 months
- Dose studied, every finding
- 1 g/day fish oil containing more than 90% ethyl-ester EPA (two 500 mg capsules daily) for 12 weeks, versus rapeseed oil and medium chain triglycerides placebo, added to antidepressant therapy
- Population, every finding
- Adults aged 18 to 75 with diabetes mellitus (type 1 or 2) and comorbid major depressive disorder, all taking antidepressant medication; 24 analysed
What moved
How to read these marks →“Subsequent linear mixed models revealed that this effect consisted of a relative increase in HDL and total cholesterol concentration in the EPA-group (table 2).”
- Increases total cholesterol (TC)
moderate
- Interests
- Industry funded
- Increases HDL cholesterol
moderate
- Interests
- Industry funded
Study record
- Design
- randomised controlled trial
- Species
- human
- Population
- Adults aged 18-75 with diabetes mellitus (type 1 or 2) and major depressive disorder on antidepressants, VU University Medical Center, Netherlands; ethyl-EPA (>90% ethyl-ester EPA) given without DHA
- Participants
- 25
- Comparator
- placebo
- Duration
- 84 days
- Endpoints measured
- 65