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Catalyst

berberineFinding

Berberine decreases body mass index

lowersModerate evidenceFindingreplicated ×4

01 · The sentence it was drawn from

“With respect to BMI reduction, the TMA showed that Met + BBR (MD − 1.85 [95% CI (− 2.76)–(− 0.94)]; P = 0.32, I2 = 0%) was superior to Met monotherapy, whereas the NMA revealed that Met + BBR was more efficacious than Met, MI, TZDs, and Met + TZDs (MDs ranging from − 1.85 [95% CI (− 2.76)–(− 0.94)] for Met to − 3.08 [95% CI (− 4.10)–(− 2.05)] for TZDs).”
Quoted verbatim from Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis.
This finding among the 83 findings on its endpoint

berberine

Body mass index

lowers

Effect as reported

−1.85mean difference

CI −2.76 to −0.94

Who
Women with polycystic ovary syndrome in 2 pooled RCTs (140 women) comparing metformin plus berberine against metformin alone, so metformin was given in both arms
Dose studied
berberine 500 mg three times daily added to metformin 500 mg three times daily

Moderate evidencePMID 34407851 · 2021

02 · The study

Study
meta-analysis
Duration
3 months

Evidence, by strength

  • strong
  • moderatethis finding
  • limited
  • very limited
  • insufficient

03 · The paper

Reproductive health
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6ZAE47KWWSJY3NVPAGV80T0