PapersPMID:34407851
Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis.
berberineWhat moved
1 findingHow to read these marks →- Decreases body mass index
moderatereplicated ×4
“With respect to BMI reduction, the TMA showed that Met + BBR (MD − 1.85 [95% CI (− 2.76)–(− 0.94)]; P = 0.32, I2 = 0%) was superior to Met monotherapy, whereas the NMA revealed that Met + BBR was more efficacious than Met, MI, TZDs, and Met + TZDs (MDs ranging from − 1.85 [95% CI (− 2.76)–(− 0.94)] for Met to − 3.08 [95% CI (− 4.10)–(− 2.05)] for TZDs).”
- Study
- meta-analysis
- Duration
- 3 months
- Effect
- −1.85 mean difference, 95% CI −2.76 to −0.94
- Dose studied
- berberine 500 mg three times daily added to metformin 500 mg three times daily
- Population
- Women with polycystic ovary syndrome in 2 pooled RCTs (140 women) comparing metformin plus berberine against metformin alone, so metformin was given in both arms
Study record
- Design
- meta-analysis
- Species
- human
- Population
- Women aged 18 to 49 years with polycystic ovary syndrome in RCTs of oral insulin sensitizers
- Participants
- 1,079
- Comparator
- an active treatment
- Duration
- not reported
- Endpoints measured
- 58
- Declined
- a direction is stated and the estimate does not support it