Skip to content
Catalyst

L-citrullineFinding

L-citrulline is converted to L-arginine

raisesInsufficient evidenceFinding

01 · The sentence it was drawn from

“On the other hand, citrulline supplementation resulted in significant increases in citrulline flux (8.4±0.4 → 61.3±3.8 μmol/kg/h, p<0.001) and de novo arginine synthesis (5.3±0.4 → 36.3±3.8 μmol/kg/h, p<0.001).”
Quoted verbatim from Impaired nitric oxide production in children with MELAS syndrome and the effect of arginine and citrulline supplementation.
This finding among the 1 finding on its endpoint

L-citrulline

L-arginine

is converted to

Who
Five children with MELAS syndrome (m.3243A>G), studied by stable isotope infusion before and after 48 hours of oral L-citrulline, on a low-nitrite and nitrate, protein-controlled diet; no control arm
Dose studied
oral L-citrulline 10 g/m2 body surface area/day if weight ≥20 kg and 500 mg/kg/dose if weight <20 kg, divided every four hours for 48 hours

Insufficient evidencePMID 26851065 · 2016

02 · The study

Study
case series
Duration
2 days

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limited
  • insufficientthis finding

03 · The paper

Molecular genetics and metabolism
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6XHTQBVXHY0TYJCSBGDJ4FB