PapersPMID:26851065
Impaired nitric oxide production in children with MELAS syndrome and the effect of arginine and citrulline supplementation.
L-citrullineWhat moved
1 findingHow to read these marks →- Is converted to L-arginine
insufficient
“On the other hand, citrulline supplementation resulted in significant increases in citrulline flux (8.4±0.4 → 61.3±3.8 μmol/kg/h, p<0.001) and de novo arginine synthesis (5.3±0.4 → 36.3±3.8 μmol/kg/h, p<0.001).”
- Study
- case series
- Duration
- 2 days
- Dose studied
- oral L-citrulline 10 g/m2 body surface area/day if weight ≥20 kg and 500 mg/kg/dose if weight <20 kg, divided every four hours for 48 hours
- Population
- Five children with MELAS syndrome (m.3243A>G), studied by stable isotope infusion before and after 48 hours of oral L-citrulline, on a low-nitrite and nitrate, protein-controlled diet; no control arm
Study record
- Design
- case series / other
- Species
- human
- Population
- five children with MELAS syndrome (m.3243A>G) given oral L-arginine and, after at least one week, oral L-citrulline (free L-citrulline, same dose and frequency as arginine), compared with five control children given neither; arginine and citrulline flux and nitric oxide production measured by stable isotope infusion
- Participants
- 10
- Comparator
- within arm
- Duration
- 2 days
- Endpoints measured
- 19