α-tocopherol/Finding
One finding, on its own
A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Decreases tumour necrosis factor alpha concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“In addition, a significant reduction in serum tumor necrosis factor-α (-35.4 ± 34.9 vs +5.6 ± 6.2 ng/L, P < .001), matrix metalloproteinase-2 (-556.7 ± 485.9 vs +60.4 ± 53.7 ng/mL, P < .001), matrix metalloproteinase-9 (-1461.5 ± 1456.0 vs +225.7 ± 488.2 ng/L, P < .001), malondialdehyde (-0.9 ± 0.5 vs +0.3 ± 0.4 μmol/L, P < .001), advanced glycation end products (-1832.2 ± 1941.6 vs +177.3 ± 324.1 arbitrary unit, P < .001), and insulin concentrations (-0.5 ± 2.7 vs +0.7 ± 1.0 μIU/mL, P = .03) was seen after the administration of vitamin E supplements compared with the placebo.”
Quoted verbatim from The effects of high-dose vitamin E supplementation on biomarkers of kidney injury, inflammation, and oxidative stress in patients with diabetic nephropathy: A randomized, double-blind, placebo-controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 1200 IU/d vitamin E vs placebo for 12 weeks
- Population
- Patients with diabetic nephropathy
The effects of high-dose vitamin E supplementation on biomarkers of kidney injury, inflammation, and oxidative stress in patients with diabetic nephropathy: A randomized, double-blind, placebo-controlled trial.2016PMID:27578124Permalink
Keep reading
- Everything the graph holds on α-tocopherol
- Every compound studied against Tumour necrosis factor alpha concentration
- How to read the evidence strength and the marks
To cite this finding: https://catalystproject.ai/e/01M5SAKC1SA6J2YG3BX3HY86DG