nicotinamide/Finding
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Decreases mitral E/e' ratio
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Importantly, NAM reduced the echocardiography-derived E/e’ ratio, a non-invasive measure of left ventricular (LV) diastolic dysfunction, to values comparable to those observed in leptin receptor-sufficient lean rats.”
Quoted verbatim from Nicotinamide for the treatment of heart failure with preserved ejection fraction.. - Study
- animal · not in humans
- Dose
- 40 mM in the drinking water
- Population
- ZSF1 obese rats (model of metabolic syndrome and HFpEF), male and female; NAM 40 mM in drinking water
Nicotinamide for the treatment of heart failure with preserved ejection fraction.2021PMID:33568522Permalink
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To cite this finding: https://catalystproject.ai/e/01M5MF8VXR03D85XRYH52P8PKS