folic acid/Finding
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A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
folic acid — no detected effect on all-site cancer incidence
Evidence strength: moderate.FindingNull result“Allocation to folic acid treatment did not have any statistically significant effect on overall cancer incidence, with 1904 (7.7%) first events in 24,799 participants allocated folic acid versus 1809 (7.3%) in 24,822 allocated control (RR 1.06; 95% CI 0.99–1.13, p=0.10: Figure 1).”
Quoted verbatim from Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals.. - Study
- meta-analysis
- Dose
- 0.5 to 5 mg folic acid daily in all trials but one (40 mg daily); one trial compared 2.5 mg with 0.02 mg
- Population
- Adults in 13 randomised trials of folic acid versus placebo (10 trials in people with or at high risk of cardiovascular disease, 3 in patients with prior colorectal adenoma); mean age 64 years
Effect 1.06 risk ratio, 95% CI 0.99 to 1.13
Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals.2013PMID:2335255210.1016/S0140-6736(12)62001-7An author is affiliated with a producerPermalink
To cite this finding: https://catalystproject.ai/e/01M5JVX97F0FBNR659VZVS8JHC