5-hydroxy-L-tryptophan/Finding
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Inhibits CD274
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“In syngeneic mouse tumor models, treatment with 100 mg/kg L-5-HTP (intraperitoneal) inhibited PD-L1 expression and exhibited antitumor effect.”
Quoted verbatim from L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression.. - Study
- animal · not in humans
- Dose
- 100 mg/kg intraperitoneal
- Population
- syngeneic mouse tumor models
L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression.2022PMID:35728870Permalink
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To cite this finding: https://catalystproject.ai/e/01M3J5W9EVZ73CN41K02AEQJ7Z