creatine/Finding
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A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Increases serum creatinine concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×3“Specifically, there was an increase in serum creatinine (mean difference 12.63 μmol/L, 95% CI 1.14 to 24.12) and decrease in eGFR (−25.79 mL/min/1.73 m2, 95% CI −44.3 to −7.25) in individuals on creatine supplementation compared to placebo.”
Quoted verbatim from Effect of creatine monohydrate on motor function in children with facioscapulohumeral muscular dystrophy: A multicenter, randomized, double-blind placebo-controlled crossover trial.. - Study
- crossover
- Duration
- 3 months
- Dose
- creatine monohydrate ~100 mg/kg/day (2.5-10 g daily by weight band) for 12 weeks per crossover period
- Population
- children aged 5-18 years with facioscapulohumeral muscular dystrophy; safety outcome, not the primary endpoint
Effect 12.63 mean difference, 95% CI 1.14 to 24.12
Effect of creatine monohydrate on motor function in children with facioscapulohumeral muscular dystrophy: A multicenter, randomized, double-blind placebo-controlled crossover trial.2025PMID:40366059Permalink
Keep reading
- Everything the graph holds on creatine
- Every compound studied against Serum creatinine concentration
- How to read the evidence strength and the marks
To cite this finding: https://catalystproject.ai/e/01M102QACN9CTAD98A1CX76S62