melatonin/Finding
One finding, on its own
A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Decreases duration of mechanical ventilation
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“However, melatonin group demonstrated significantly lower serum HMGB-1 and NT-pro-BNP concentrations along with shorter duration of MV and less need for oxygen therapy and shorter length of NICU stay compared to control group.”
Quoted verbatim from Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension.. - Study
- RCT
- Dose
- Oral melatonin 10 mg/kg/day for five doses, started within the first 24 h; melatonin tablets crushed, suspended in 5 mL normal saline and given by orogastric tube, in addition to standard care
- Population
- Neonates of at least 36 weeks' gestation with persistent pulmonary hypertension of the newborn (PPHN), neonatal intensive care unit, Tanta University Hospitals, Egypt; n=80 randomised and analysed (40 melatonin plus standard care, 40 placebo plus standard care); duration of mechanical ventilation was a pre-specified SECONDARY clinical outcome (primary outcome was LV function at end of therapy, with LV-GLS the principal endpoint); open to clinicians, outcome assessors blinded
Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension.2026PMID:41954764Permalink
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To cite this finding: https://catalystproject.ai/e/01M0Q30369B0TRN6JXGN3XZF81