systemic sclerosis
Findings
No curated finding names systemic sclerosis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension.
Definition from the Mondo Disease Ontology (MONDO:0005100), read 2026-09-29. CC BY 4.0.
Features
86 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of the gastrointestinal tractHPOHP:0011024
- Very frequent (80% to 99% of cases)
- Antinuclear antibody positivityHPOHP:0003493
- Very frequent (80% to 99% of cases)
- ArthralgiaHPOHP:0002829
- Very frequent (80% to 99% of cases)
- Cutaneous sclerotic plaqueHPOHP:0031359
- Very frequent (80% to 99% of cases)
- MyalgiaHPOHP:0003326
- Very frequent (80% to 99% of cases)
- Raynaud phenomenonHPOHP:0030880
- Very frequent (80% to 99% of cases)
Show the remaining 74
- Anti-angiotensin receptor type-1 antibody positivityHPOHP:0034094
- Frequent (30% to 79% of cases)
- Anti-angiotensin-converting enzyme 2 antibody positivityHPOHP:0034117
- Frequent (30% to 79% of cases)
- Anti-B23 antibody positivityHPOHP:0034089
- Frequent (30% to 79% of cases)
- Anti-bicaudal D2 antibody positivityHPOHP:0034082
- Frequent (30% to 79% of cases)
- Anti-carbonic anhydrase II antibody positivityHPOHP:0033394
- Frequent (30% to 79% of cases)
- Anti-centromere antibody positivityHPOHP:0030873
Where it sits
- A kind of
Other names
3 names
Resolves to: systemic sclerosis
- Also called
- Scleroderma, systemicSScSystemic Scleroderma