diffuse cutaneous systemic sclerosis
Findings
No curated finding names diffuse cutaneous systemic sclerosis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Diffuse cutaneous systemic sclerosis (dcSSc) is a subtype of Systemic Sclerosis (SSc) characterized by truncal and acral skin fibrosis with an early and significant incidence of diffuse involvement (interstitial lung disease, oliguric renal failure, diffuse gastrointestinal disease, and myocardial involvement).
Definition from the Mondo Disease Ontology (MONDO:0016356), read 2026-09-29. CC BY 4.0.
Features
26 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of the skinHPOHP:0000951
- Very frequent (80% to 99% of cases)
- AutoimmunityHPOHP:0002960
- Very frequent (80% to 99% of cases)
- DyspneaHPOHP:0002094
- Very frequent (80% to 99% of cases)
- Gastroesophageal refluxHPOHP:0002020
- Very frequent (80% to 99% of cases)
- Narrow foramen obturatoriumHPOHP:0100958
- Very frequent (80% to 99% of cases)
- OliguriaHPOHP:0100520
- Very frequent (80% to 99% of cases)
- Pulmonary infiltratesHPOHP:0002113
- Very frequent (80% to 99% of cases)
- ArthralgiaHPOHP:0002829
- Frequent (30% to 79% of cases)
- ArthritisHPOHP:0001369
- Frequent (30% to 79% of cases)
- Carious teethHPOHP:0000670
- Frequent (30% to 79% of cases)
- DyspareuniaHPOHP:0030016
- Frequent (30% to 79% of cases)
- DysphagiaHPOHP:0002015
- Frequent (30% to 79% of cases)
Show the remaining 14
- Flexion contractureHPOHP:0001371
- Frequent (30% to 79% of cases)
- MalabsorptionHPOHP:0002024
- Frequent (30% to 79% of cases)
- Muscle weaknessHPOHP:0001324
- Frequent (30% to 79% of cases)
- OsteolysisHPOHP:0002797
- Frequent (30% to 79% of cases)
- Pulmonary fibrosisHPOHP:0002206
- Frequent (30% to 79% of cases)
- Skin ulcerHPOHP:0200042
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
4 names
Resolves to: diffuse cutaneous systemic sclerosis
- Also called
- diffuse cutaneous systemic sclerodermadSScprogressive cutaneous systemic sclerodermaprogressive cutaneous systemic sclerosis